Tag: depression

What do 90% of Americans do first thing when they wake up in the morning? They get out of bed, go downstairs and reach for some coffee or tea. Why? It gives them energy, motivation, focus and transforms them from grumpy, sleepy zombies into happy little worker bees, buzzing about. This is because of caffeine’s effect on their biochemistry. 

Caffeine blocks adenosine in the brain, which is a neurotransmitter that causes sleepiness. Caffeine also causes dopamine to be released, which is responsible for the increase in attention, motivation and improved mood, as well as norepinephrine to be released, which makes you alert and energized. Norepinephrine is also why you’ll find yourself on the john half an hour after your first cup.

Caffeine is just one substance that you can use to alter your biochemistry in a favorable fashion. I’d love to help you learn how to do just that, but first you have to agree that you understand that this is just a website, that I’m not a doctor, and that anything you decide to do because of this article should be checked out with your primary care physician first, especially if you’re on prescription meds or have depression, anxiety or any other mental illness. There are no cures presented here, just ways to help you get the most out of life.

Let’s get on with it.

First, we need to understand a few terms and concepts. A neurotransmitter is a molecule used for communication between neurons in your brain and nervous system, and can be either excitatory, inhibitory, or both.

Excitatory neurotransmitters include

• dopamine
• epinephrine (adrenalin)
• norepinephrine
• acetylcholine
• PEA
• glutamate

Inhibitory neurotransmitters include

• GABA
• serotonin
• melatonin
• glycine

Your mood, outlook and energy levels are strongly correlated to the exact ratio and proportions of the neurotransmitters that are active in your brain at any given moment. This means that if you can tweak the levels of your neurotransmitters, you can positively steer your mood and outlook as you see fit. 

Don’t overdo it, though. The body is always trying to maintain homeostasis, and increasing one neurotransmitter too much leads to its receptors becoming de-sensitized, and eventually even a loss in those receptors – this is how addiction and withdrawal forms.

Increasing dopamine – Results in increased drive and motivation, increased pleasure gotten out of most activities, and improves mood and confidence. You’ll remember this feeling as the first cup of coffee of the day, having sex, eating delicious food, or engaging in any rewarding activity

Beautiful, beautiful dopamine. My favorite neurotransmitter. This is responsible for the buzz or high coming from caffeine, cocaine, adderall and other ADHD meds, as well as the more subtle “high” to be achieved from completing rewarding tasks. Go hike a mountain, and when you reach the summit, drink deep from the springs of dopamine.

There are two methods you want to utilize to enhance dopamine, the first of which is making use of long term supplements and strategies to resensitize and increase dopamine receptors. This will have the net effect of causing you to be more motivated, energetic, confident and focused, as well as receiving more pleasure out of most actives, without having to take any substance. It will also enhance the effects of short-term dopaminergics, making them more effective.

You can simply have a few cups of gynostemma tea, an adaptogenic herb from China, to resensitize your dopamine neurons. Inositol works as well, but I find it easier to simply drink a few cups of tea. On top of this, cut back on activities that deplete dopamine – things like constantly texting, checking Facebook and other social media, drinking too much alcohol or coffee, or any other semi-addictive behavior.

Both intense physical exercise as well as fasting are perhaps the strongest methods to re-sensitize the brain to dopamine, and act as a “reboot” for the brain in general. If you aren’t getting regular exercise we need to sit down and have a serious talk, and I strongly advise fasting at least a full day once a month.

Remember, these are long term strategies, and while you may notice benefits within a week or two, it’s ideally something you’d continue to do throughout life.

You can also use occasional supplements to increase the body’s production of dopamine, in much the same way you can use coffee as a morning or mid-afternoon pick me up. L-Tyrosine has been my go-to dopaminergic substance, as it is easily converted into dopamine within the body.

You can also use DL-Phenylalanine, as some of the Phenylalanine will be converted into L-Tyrosine and thus dopamine, and some of it will be converted into PEA, a feel-good neurotransmitter that some have dubbed the “love chemical”. You can also get hefty doses of PEA and the endogenous cannabinoid anandamide (ananda = bliss in Sanskrit), from cacao, either in powder form or in a very dark chocolate bar. Both are very potent mood-boosting compounds.

Further, dopamine can be converted into epinephrine and norepinephrine, two more neurotransmitters that increase energy and alertness.

Have a serious coffee addiction? Try cutting the amount of coffee you consume in half, and use a bit of L-Tyrosine or Phenylalanine for a synergistic energy boost. Both work well any time you need a pick-me-up or need the extra focus and attention. Use anywhere from 100 to 1000 mg, at once or split evenly in 3 doses throughout the day. Take note that those on prescription MAOIs, those with hypertension or those with Phenylketonuria should not take tyrosine or phenylalanine.

GABA – An increase in GABA results in feeling relaxed and at ease. Prescription anti-anxiety meds act on GABA receptors in the brain. That relaxing feeling you get after drinking a nice glass of wine is due to alcohol releasing GABA within the brain.

GABA, which stands for gamma-aminobutyric acid, is the main inhibitory neurotransmitter within the brain. GABA produces a nice relaxed feeling, and is involved in decreasing stress and calming the brain enough to fall asleep.

Increasing GABA is especially useful for those who are stressed or suffer from anxiety. Instead of taking pharmaceutical drugs, why not just try to increase the body’s own production of GABA?

According to this study, performing one hour of yoga resulted in an average of 27% increase in GABA levels, which is huge. 

One of the best ways to relieve anxiety is by using ashwagandha, one of my favorite Ayurvedic herbs. It’s been found to a be a potent GABA-mimetic, mimicking the effects of GABA without actually changing brain levels of the neurotransmitter. Perhaps even more beneficial is it’s rejuvenating effect on the brain –

Ashwagandha, its constituents and the metabolites of its constituents promote the growth of nerves after taking it for 7 days… It has anxiolytic effect [relieves anxiety] and improves energy levels and mitochondrial health.

Ashwagandha also has a unique ability to lower the stress hormone cortisol. A 2008 double blind, placebo controlled study showed that, “Over a 60-day period, doses ranging from 125 mg to 500 mg daily of a patented ashwagandha extract (Sensoril®) significantly improved scores on a standardized measurement of stress intensity, and also favorably modulated several biomarkers… Moreover, at the end of the study period subjects that received 500 mg of ashwagandha daily had cortisol levels nearly 30% lower than subjects who took a placebo, and their DHEA-s levels were significantly higher as well.”

I recommend this ashwagandha product, which contains 250 mg of the patented ashwagandha extract Sensoril used in the study above. It’s 10 bucks, you have no excuse.

Another excellent choice for reducing anxiety and inducing a sense of calm is L-Theanine, a rare amino-acid like compound found only in green tea.

Straight from the LEF website, L-Theanine, “has traditionally been used to enhance relaxation and improve concentration and learning ability (Vuong 2011; Wakabayashi 2011; Nathan 2006).

L-theanine is chemically related to the neurotransmitter glutamate, and binds to glutamate receptors in the brain (Cho 2008). Unlike glutamate, however, which can cause a state called excitotoxicity that can destroy nerve cells, L-theanine protects brain cells against excitotoxicity, calming the nerve networks in the brain (Kakuda 2002; Nagasawa 2004; Di 2010).

L-theanine reduces evidence of anxiety and depression in several different animal models of stress (Yin 2011; Heese 2009). In one animal model, L-theanine led to decreases in nearly all frequencies of brainwave activity, indicating a state of calmness and relaxation (Dimpfel 2007).

In one study, healthy subjects took a soft drink containing green tea enriched with L-theanine while their brainwave power was measured (Dimpfel 2007). Power was initially reduced in all frequencies and areas during the first hour, indicating relaxation. Later changes indicated both an increase in mental performance and a higher degree of relaxation. In this case, L-theanine seemed to produce desirable increases in attention, accompanied by durable relaxation—that means subjects could concentrate better without being distracted by anxiety.

A third trial concluded that L-theanine plays a general role in sustaining attention during a long-term difficult task (Gomez-Ramirez 2009).”

L-Theanine has such wide-ranging and strong effects because it increases brain levels of GABA, Dopamine and Serotonin, as well as having affinities for a few other receptors involved in attention and cognition.

As I commented on in my post about A Few Effective Biohacks, combining L-Theanine with caffeine is a powerful brain boosting combo – all the benefits of increased attention, mood and energy from the caffeine, as well as the neuroprotective and zen-like focus from L-Theanine. Some people recommend a dosage of 2:1 L-theanine to caffeine ratio, but I get better effects from a 1:1 ratio. You can play around with the doses and see what works best for you.

You can supplement with straight L-Theanine, or you can consume matcha green tea, which has high levels of L-Theanine, more caffeine than regular green tea, as well substantially more EGCG, the potent anti-cancer, fat-burning antioxidant.

Serotonin – Serotonin is responsible for feelings of relaxation, as well helping to curb hunger, improve mood and help with sleeping patterns. You know that warm, happy, comfortable feeling you get after eating a large bowl of ice cream or anything sugary? That’s serotonin.

I’m personally not a big fan of trying to increase serotonin. While I like dopamine’s mood- and energy-boosting effects, and GABA is useful for focus or relaxing, serotonin makes me feel dopey and lazy. Everyone’s different however, and many people do benefit from a little boost in serotonin, so I don’t want to leave it out.

Serotonin is the neurotransmitter targeted by most anti-depressants, but considering up to 50% of people don’t respond to these anti-depressants, I wouldn’t be quick to claim serotonin is the “happiness” neurotransmitter. That said, if you’re on anti-depressants or taking any MAOIs, don’t try to supplement with any extra serotonin, and nobody should take huge doses of serotonin supplements (or any other supplements) as it can lead to serotonin syndrome.

The reason sugar leads to a serotonin buzz is because the insulin released from consuming sugar sweeps most other amino acids out of the blood stream, but leaves behind tryptophan. Tryptophan then makes its way to the brain unimpeded by other amino acids, where it is first converted in 5-HTP, and then into 5-HT, or serotonin.

While you can supplement with 5-HTP, I suggest you don’t as there is concern about it affecting the heart, and instead simply eat more carbs or supplement with tryptophan.

Acetylcholine – While being a very important neurotransmitter, acetylcholine doesn’t have much of a “feeling” or affect your mood. It is extremely important for memory and learning, however, and may be involved in creativity.

This is the neurotransmitter you want to focus on if you have a lot of studying to do, if you’re trying to learn something quick, or if you just have bad memory. Many people who use nootropics, or cognitive enhancers, have at least one supplement that tries to increase levels of acetylcholine within the brain.

To increase acetylcholine, you can simply consume more choline – the best food sources are liver (just eat it), eggs, grass-fed milk and cheese products, peanuts and cruciferous veggies. You can also supplement with choline – Alpha GPC is a highly bioavailable source of choline, or you can use Acetyl-l-carnitine (ALCAR), which can increase levels of acetylcholine by donating its acetyl group. ALCAR has a whole host of other benefits as well, including being a potent neural antioxidant, helping the mitochondria to burn fat for energy, and is a strong cognitive enhancer in its own right.

In conclusion, many people are unaware that you can tweak your biochemistry to get an edge in life, or just to help you unwind or handle stressful events calmly. This knowledge can make a huge difference in your life and your ability to get things done.